Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2011 (2011), Article ID 130406, 7 pages
http://dx.doi.org/10.1155/2011/130406
Hypothesis

Occult Cerebrovascular Disease and Late-Onset Epilepsy: Could Loss of Neurovascular Unit Integrity Be a Viable Model?

1Department of Acute Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
2Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK
3School of Cancer and Imaging Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
4Department of Neurology, Royal Preston Hospital, Fulwood, Preston PR2 9HT, UK

Received 27 August 2010; Revised 13 December 2010; Accepted 30 December 2010

Academic Editor: Alon Friedman

Copyright © 2011 Lorna M. Gibson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Craig and R. C. Tallis, “General practitioner management of adult-onset epilepsyanalysed,” Care Elderly, vol. 3, pp. 69–72, 1991. View at Google Scholar
  2. R. Tallis, G. Hall, I. Craig, and A. Dean, “How common are epileptic seizures in old age?” Age and Ageing, vol. 20, no. 6, pp. 442–448, 1991. View at Google Scholar · View at Scopus
  3. J. Burn, M. Dennis, J. Bamford, P. Sandercock, D. Wade, and C. Warlow, “Epileptic seizures after a first stroke: the Oxfordshire community stroke project,” British Medical Journal, vol. 315, no. 7122, pp. 1582–1587, 1997. View at Google Scholar · View at Scopus
  4. P. Cleary, S. Shorvon, and R. Tallis, “Late-onset seizures as a predictor of subsequent stroke,” The Lancet, vol. 363, no. 9416, pp. 1184–1186, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. C. L. M. Sudlow, “Epilepsy and stroke,” The Lancet, vol. 363, no. 9416, pp. 1175–1176, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Cordonnier, R. Al-Shahi Salman, and J. Wardlaw, “Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting,” Brain, vol. 130, no. 8, pp. 1988–2003, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. B. R. Reed, J. L. Eberling, D. Mungas, M. Weiner, J. H. Kramer, and W. J. Jagust, “Effects of white matter lesions and lacunes on cortical function,” Archives of Neurology, vol. 61, no. 10, pp. 1545–1550, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. R. B. Buxton, K. Uludaǧ, D. J. Dubowitz, and T. T. Liu, “Modeling the hemodynamic response to brain activation,” NeuroImage, vol. 23, supplement 1, pp. S220–S233, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Parkes and P. S. Tofts, “Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability,” Magnetic Resonance in Medicine, vol. 48, no. 1, pp. 27–41, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Jezzard and R. B. Buxton, “The clinical potential of functional magnetic resonace imaging,” Journal of Magnetic Resonance Imaging, vol. 23, no. 6, pp. 787–793, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Kobayashi, K. Okada, and K. Yamashita, “Incidence of silent lacunar lesion in normal adults and its relation to cerebral blood flow and risk factors,” Stroke, vol. 22, no. 11, pp. 1379–1383, 1991. View at Google Scholar · View at Scopus
  12. H. Nakane, S. Ibayashi, K. Fujii et al., “Cerebral blood flow and metabolism in patients with silent brain infarction: occult misery perfusion in the cerebral cortex,” Journal of Neurology Neurosurgery and Psychiatry, vol. 65, no. 3, pp. 317–321, 1998. View at Google Scholar · View at Scopus
  13. J. De Reuck, D. Decoo, P. Boon, K. Strijckmans, P. Goethals, and I. Lemahieu, “Late-onset epileptic seizures in patients with leukoaraiosis: a positron emission tomographic study,” European Neurology, vol. 36, no. 1, pp. 20–24, 1996. View at Google Scholar · View at Scopus
  14. R. A. Trivedi, H. A. L. Green, J. U-King-Im et al., “Cerebral haemodynamic disturbances in patients with moderate carotid artery stenosis,” European Journal of Vascular and Endovascular Surgery, vol. 29, no. 1, pp. 52–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. T. L. Davis, K. K. Kwong, R. M. Weisskoff, and B. R. Rosen, “Calibrated functional MRI: mapping the dynamics of oxidative metabolism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 4, pp. 1834–1839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. P. A. Chiarelli, D. P. Bulte, R. Wise, D. Gallichan, and P. Jezzard, “A calibration method for quantitative BOLD fMRI based on hyperoxia,” NeuroImage, vol. 37, no. 3, pp. 808–820, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. A. Goodwin, R. Vidyasagar, G. M. Balanos, D. Bulte, and L. M. Parkes, “Quantitative fMRI using hyperoxia calibration: reproducibility during a cognitive Stroop task,” NeuroImage, vol. 47, no. 2, pp. 573–580, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. D. P. Bulte, K. Drescher, and P. Jezzard, “Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI,” Magnetic Resonance in Medicine, vol. 61, no. 2, pp. 391–398, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. T. H. Schwartz, “Neurovascular coupling and epilepsy: hemodynamic markers forlocalizing and predicting seizure onset,” Epilepsy Current, vol. 7, no. 4, pp. 91–94, 2007. View at Google Scholar
  20. C. S. Hawco, A. P. Bagshaw, Y. Lu, F. Dubeau, and J. Gotman, “BOLD changes occur prior to epileptic spikes seen on scalp EEG,” NeuroImage, vol. 35, no. 4, pp. 1450–1458, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Valmier, J. Touchon, and M. Baldy-Moulinier, “Interictal regional cerebral blood flow during non specific activation test in partial epilepsy,” Journal of Neurology Neurosurgery and Psychiatry, vol. 52, no. 3, pp. 364–371, 1989. View at Google Scholar · View at Scopus
  22. L. Niehaus, U. C. Wieshmann, and B. U. Meyer, “Changes in cerebral hemodynamics during simple partial motor seizures,” European Neurology, vol. 44, no. 1, pp. 8–11, 2000. View at Google Scholar · View at Scopus
  23. R. Wiest, F. von Bredow, K. Schindler et al., “Detection of regional blood perfusion changes in epileptic seizures with dynamic brain perfusion CT-A pilot study,” Epilepsy Research, vol. 72, no. 2-3, pp. 102–110, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Rupprecht, M. Schwab, C. Fitzek, O. W. Witte, C. Terborg, and G. Hagemann, “Hemispheric hypoperfusion in postictal paresis mimics early brain ischemia,” Epilepsy Research, vol. 89, no. 2-3, pp. 355–359, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. De Reuck and G. Van Maele, “Acute ischemic stroke treatment and the occurrence of seizures,” Clinical Neurology and Neurosurgery, vol. 112, no. 4, pp. 328–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. L. H. Rodan, R. I. Aviv, D. J. Sahlas, B. J. Murray, J. P. Gladstone, and D. J. Gladstone, “Seizures during stroke thrombolysis heralding dramatic neurologic recovery,” Neurology, vol. 67, no. 11, pp. 2048–2049, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. D. A. Sun, S. Sombati, and R. J. DeLorenzo, “Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy",” Stroke, vol. 32, no. 10, pp. 2344–2350, 2001. View at Google Scholar · View at Scopus
  28. D. A. Sun, S. Sombati, R. E. Blair, and R. J. DeLorenzo, “Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy,” Cell Calcium, vol. 35, no. 2, pp. 155–163, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Terborg, F. Gora, C. Weiller, and J. Röther, “Reduced vasomotor reactivity in cerebral microangiopathy: a study with near-infrared spectroscopy and transcranial Doppler sonography,” Stroke, vol. 31, no. 4, pp. 924–929, 2000. View at Google Scholar · View at Scopus
  30. M. L. Schroeter, S. Cutini, M. M. Wahl, R. Scheid, and D. Yves von Cramon, “Neurovascular coupling is impaired in cerebral microangiopathy—an event-related Stroop study,” NeuroImage, vol. 34, no. 1, pp. 26–34, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. M. Wardlaw, P. A. G. Sandercock, M. S. Dennis, and J. Starr, “Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?” Stroke, vol. 34, no. 3, pp. 806–812, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Roob and F. Fazekas, “Magnetic resonance imaging of cerebral microbleeds,” Current Opinion in Neurology, vol. 13, no. 1, pp. 69–73, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Seiffert, J. P. Dreier, S. Ivens et al., “Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex,” Journal of Neuroscience, vol. 24, no. 36, pp. 7829–7836, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. David, L. P. Cacheaux, S. Ivens et al., “Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?” Journal of Neuroscience, vol. 29, no. 34, pp. 10588–10599, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. U. Heinemann, S. Gabriel, R. Jauch et al., “Alterations of glial cell function in temporal lobe epilepsy,” Epilepsia, vol. 41, supplement 6, pp. S185–S189, 2000. View at Google Scholar · View at Scopus
  36. P. A. Armitage, A. J. Farrall, T. K. Carpenter, F. N. Doubal, and J. M. Wardlaw, “Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities,” Magnetic Resonance Imaging, 2010. Epub ahead of print. View at Publisher · View at Google Scholar
  37. G. J. Zipfel, H. Han, A. L. Ford, and J. M. Lee, “Cerebral amyloid angiopathy progressive disruption of the neurovascular unit,” Stroke, vol. 40, no. 3, supplement, pp. S16–S19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Greenberg, J. P. G. Vonsattel, J. W. Stakes, M. Gruber, and S. P. Finklestein, “The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage,” Neurology, vol. 43, no. 10, pp. 2073–2079, 1993. View at Google Scholar · View at Scopus
  39. K. Karabatsou, B. R. F. Lecky, N. G. Rainov, J. C. Broome, and R. P. White, “Cerebral amyloid angiopathy with symptomatic or occult subarachnoid haemorrhage [1],” European Neurology, vol. 57, no. 2, pp. 103–105, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Kinnecom, M. H. Lev, L. Wendell et al., “Course of cerebral amyloid angiopathy-related inflammation,” Neurology, vol. 68, no. 17, pp. 1411–1416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. L. M. Gibson, L. M. Parkes, and H. C. A. Emsley, “Occult cerebrovascular disease in late-onset epilepsy: a literature review and novel hypothesis,” in Proceedings of the 18th Meeting of the European Neurological Society, Nice, France, June 2008, (poster).
  42. L. M. Gibson, L. M. Parkes, and H. C. A. Emsley, “Occult cerebrovascular disease in late-onset epilepsy: a literature review and novel hypothesis,” Journal of Neurology, vol. 255, supplement 2, p. 102, 2008. View at Google Scholar