Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2011 (2011), Article ID 469046, 10 pages
http://dx.doi.org/10.1155/2011/469046
Research Article

Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats

1Department of Pharmacology, University of Melbourne, Medical Building 181, Parkville VIC 3010, Australia
2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX13QX, UK
3Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany

Received 11 August 2010; Revised 9 January 2011; Accepted 18 January 2011

Academic Editor: Alon Friedman

Copyright © 2011 H. B. Stolp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Several neurological disorders have been linked to inflammatory insults suffered during development. We investigated the effects of neonatal systemic inflammation, induced by LPS injections, on blood-brain barrier permeability, endothelial tight junctions and behaviour of juvenile (P20) and adult rats. LPS-treatment resulted in altered cellular localisation of claudin-5 and changes in ultrastructural morphology of a few cerebral blood vessels. Barrier permeability to sucrose was significantly increased in LPS treated animals when adult but not at P20 or earlier. Behavioural tests showed that LPS treated animals at P20 exhibited altered behaviour using prepulse inhibition (PPI) analysis, whereas adults demonstrated altered behaviour in the dark/light test. These data indicate that an inflammatory insult during brain development can change blood-brain barrier permeability and behaviour in later life. It also suggests that the impact of inflammation can occur in several phases (short- and long-term) and that each phase might lead to different behavioural modifications.