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Case Reports in Cardiology
Volume 2014, Article ID 213842, 3 pages
Case Report

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy

1Department of Medicine, Kingston General Hospital, Queen’s University, Kingston, ON, Canada K7L 3N6
2Department of Medicine, Yale University, Bridgeport Hospital, Bridgeport, CT 06610, USA
3School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK
4Cardiac Electrophysiology and Pacing, Kingston General Hospital, Queen’s University, Kingston, ON, Canada K7L 2V7

Received 11 March 2014; Accepted 29 March 2014; Published 14 April 2014

Academic Editor: Hajime Kataoka

Copyright © 2014 Michael Gysel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 71-year-old woman collapsed while working as a grocery store cashier. CPR was performed and an AED revealed torsades de pointes (TdP). She was subsequently defibrillated resulting in restoration of sinus rhythm with a QTc interval of 544 msec. Further evaluation revealed a diagnosis of Takotsubo Cardiomyopathy (TCM) contributing to the development of a multifactorial acquired long QT syndrome (LQTS). The case highlights the role of TCM as a cause of LQTS in the setting of multiple risk factors including old age, female gender, hypokalemia, and treatment with QT prolonging medications. It also highlights the multifactorial nature of acquired LQTS and lends support to growing evidence of an association with TCM.