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Case Reports in Cardiology
Volume 2014, Article ID 293476, 4 pages
http://dx.doi.org/10.1155/2014/293476
Case Report

Bleeding Complication of Triple Therapy of Rivaroxaban, Prasugrel, and Aspirin: A Case Report and General Discussion

Department of Internal Medicine, Michigan State University, B-301 Clinical Center, East Lansing, MI 48824, USA

Received 14 December 2013; Accepted 13 February 2014; Published 11 March 2014

Academic Editors: R. Akdemir, M.-H. Jim, and G. Pontone

Copyright © 2014 Dane D. Gruenebaum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. B. King III, S. C. Smith Jr., J. W. Hirshfeld Jr. et al., “2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association task force on practice guidelines,” Circulation, vol. 117, no. 2, pp. 261–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Connolly, J. Pogue, R. Hart et al., “Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial,” The Lancet, vol. 367, no. 9526, pp. 1903–1912, 2006. View at Google Scholar
  3. R. L. McNamara, L. J. Tamariz, J. B. Segal, and E. B. Bass, “Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography,” Annals of Internal Medicine, vol. 139, no. 12, pp. 1018–1033, 2003. View at Google Scholar · View at Scopus
  4. R. G. Hart, L. A. Pearce, and M. I. Aguilar, “Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation,” Annals of Internal Medicine, vol. 146, no. 12, pp. 857–867, 2007. View at Google Scholar · View at Scopus
  5. M. B. Leon, D. S. Baim, J. J. Popma et al., “A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting,” The New England Journal of Medicine, vol. 339, no. 23, pp. 1665–1671, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. D. P. Faxon, J. W. Eikelboom, P. B. Berger et al., “Antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting: a North American perspective: executive summary,” Circulation: Cardiovascular Interventions, vol. 4, no. 5, pp. 522–534, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. H.-J. Zhao, Z.-T. Zheng, Z.-H. Wang et al., ““Triple therapy” rather than “triple threat”: a meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment,” Chest, vol. 139, no. 2, pp. 260–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Hansen, R. Sørensen, M. T. Clausen et al., “Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation,” Archives of Internal Medicine, vol. 170, no. 16, pp. 1433–1441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Sørensen, M. L. Hansen, S. Z. Abildstrom et al., “Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data,” The Lancet, vol. 374, no. 9706, pp. 1967–1974, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. S. Paikin, D. S. Wright, M. A. Crowther, S. R. Mehta, and J. W. Eikelboom, “Triple antithrombotic therapy in patients with atrial fibrillation and coronary artery stents,” Circulation, vol. 121, no. 18, pp. 2067–2070, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. J. Dewilde, T. Oirbans, F. W. Verheugt et al., “Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial,” The Lancet, vol. 381, no. 9872, pp. 1107–1115, 2013. View at Publisher · View at Google Scholar
  12. V. Fuster, L. E. Ryden, D. S. Cannom et al., “ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society,” Circulation, vol. 114, no. 7, pp. e257–e354, 2006. View at Google Scholar
  13. J. J. You, D. E. Singer, P. A. Howard et al., “Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines,” Chest, vol. 141, pp. e531S–e575S, 2012. View at Publisher · View at Google Scholar
  14. T. Y. Wang, L. A. Robinson, F.-S. Ou et al., “Discharge antithrombotic strategies among patients with acute coronary syndrome previously on warfarin anticoagulation: physician practice in the CRUSADE registry,” American Heart Journal, vol. 155, no. 2, pp. 361–368, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. R. Patel, K. W. Mahaffey, J. Garg et al., “Rivaroxaban versus warfarin in nonvalvular atrial fibrillation,” The New England Journal of Medicine, vol. 365, no. 10, pp. 883–891, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Mega, E. Braunwald, S. Mohanavelu et al., “Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial,” The Lancet, vol. 374, no. 9683, pp. 29–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. L. Mega, E. Braunwald, S. D. Wiviott et al., “Rivaroxaban in patients with a recent acute coronary syndrome,” The New England Journal of Medicine, vol. 366, no. 1, pp. 9–19, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. J. L. Mega, E. Braunwald, S. D. Wiviott et al., “Comparison of the efficacy and safety of two rivaroxaban doses in acute coronary syndrome (from ATLAS ACS 2-TIMI 51),” American Journal of Cardiology, vol. 112, no. 4, pp. 472–478, 2013. View at Publisher · View at Google Scholar
  19. S. D. Wiviott, D. Trenk, A. L. Frelinger et al., “Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the prasugrel in comparison to clopidogrel for inhibition of platelet activation and aggregation-thrombolysis in myocardial infarction 44 trial,” Circulation, vol. 116, no. 25, pp. 2923–2932, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. D. Wiviott, E. Braunwald, C. H. McCabe et al., “Prasugrel versus clopidogrel in patients with acute coronary syndromes,” The New England Journal of Medicine, vol. 357, no. 20, pp. 2001–2015, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. S. R. Mehta, J.-F. Tanguay, J. W. Eikelboom et al., “Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial,” The Lancet, vol. 376, no. 9748, pp. 1233–1243, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. D. L. Bhatt, J. Scheiman, N. S. Abraham et al., “ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use,” The American Journal of Gastroenterology, vol. 103, no. 11, pp. 2890–2907, 2008. View at Publisher · View at Google Scholar · View at Scopus