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Case Reports in Cardiology
Volume 2014 (2014), Article ID 853921, 5 pages
http://dx.doi.org/10.1155/2014/853921
Case Report

A Case of Severe Carotid Stenosis in a Patient with Familial Hypercholesterolemia without Significant Coronary Artery Disease

1Marcor Clinic, Maximum Body Care and Recovery, Avenida Presidente Vargas 811, 64200-200 Parnaíba, PI, Brazil
2Genetics and Molecular Biology Laboratory, Federal University of Piauí, Avenida São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil
3Faculty of Medicine, Federal University of Piauí, Avenida São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil
4Faculty of Medicine, Federal University of Piauí, R. Doutor Natan Portela Nunes s/n, 64049-550 Teresina, PI, Brazil

Received 21 August 2014; Accepted 10 October 2014; Published 23 October 2014

Academic Editor: Kenei Shimada

Copyright © 2014 Marcos Aurélio Lima Barros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by elevated low-density lipoprotein cholesterol levels in the blood. In its heterozygous form, it occurs in 1 in 500 individuals in the general population. It is an important contributor to the early onset of coronary artery disease (CAD), accounting for 5–10% of cases of cardiovascular events in people younger than 50 years. Atherogenesis triggered by hypercholesterolemia generally progresses faster in the coronary arteries, followed by the subsequent involvement of other arteries such as the carotids. Thus, symptoms of CAD commonly appear before the onset of significant carotid stenosis. Herein, we report the case of a patient with untreated FH who had severe carotid atherosclerosis at the age of 46 years but had no evidence of significant CAD.