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Case Reports in Cardiology
Volume 2016 (2016), Article ID 1490181, 4 pages
http://dx.doi.org/10.1155/2016/1490181
Case Report

MELAS Syndrome with Cardiac Involvement: A Multimodality Imaging Approach

1Department of Radiology and Interventional Radiology, IRCCS AOU San Martino, IST Genova, Largo Benzi 10, 16100 Genova, Italy
2Clinic of Cardiovascular Disease, University of Genoa, Viale Benedetto XV n6, 16143 Genova, Italy
3Neuromuscular and Molecular Medicine Unit, IRCCS Stella Maris Foundation, Pisa, Italy
4Division of Cardiology, IRCCS AOU San Martino, IST Genova, Largo Benzi 10, 16100 Genova, Italy
5IRCCS AOU San Martino, IST Genova, Largo Benzi 10, 16100 Genova, Italy
6First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Viale Benedetto XV n6, 16143 Genova, Italy

Received 13 August 2016; Accepted 22 September 2016

Academic Editor: Kenei Shimada

Copyright © 2016 Sara Seitun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 49-year-old man presented with chest pain, dyspnea, and lactic acidosis. Left ventricular hypertrophy and myocardial fibrosis were detected. The sequencing of mitochondrial genome (mtDNA) revealed the presence of A to G mtDNA point mutation at position 3243 (m.3243A>G) in gene. Diagnosis of cardiac involvement in a patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS) was made. Due to increased risk of sudden cardiac death, cardioverter defibrillator was implanted.