Case Report
Camrelizumab-Related Lethal Arrhythmias and Myasthenic Crisis in a Patient with Metastatic Thymoma
Table 1
Results of routine laboratory test.
| | Parameter | Normal range | Before ICI use | On admission | Day 2 | Day 3 | Day 4 | Day 5 |
| | TnI (ng/mL) | <0.030 | 0.01 | 13.94 | 36.05 | 63.0 | 46.0 | 20.8 | | CK-MB (ng/mL) | 0.60-6.30 | 1.10 | 213.70 | 233.6 | 135.1 | 71.2 | 33.8 | | CK (U/L) | 38.0-174.0 | 20.4 | 8811.4 | 4051.3 | 2245.9 | 1259.5 | 867.9 | | ALT (U/L) | 7-40 | 12 | 290 | | 273 | | 183 | | AST (U/L) | 13-35 | 18 | 805 | | 566 | | 155 | | Serum K (mmol/L) | 3.5-5.3 | 3.65 | 4.19 | 3.74 | 4.58 | 4.87 | 4.92 | | Serum Mg (mmol/L) | 0.75-1.02 | 0.82 | 0.85 | 0.85 | 0.99 | 1.01 | 1.04 | | Scr (μmol/L) | 41.0-81.0 | 58.4 | 73.4 | 43.2 | 96.2 | 96.2 | 105.6 | | GFR (mL/min) | 75.0-300.0 | 94.1 | 72.2 | 141.2 | 52.9 | 60.5 | 47.5 | | Arterial pH | 7.37-7.45 | | 7.46 | 7.40 | 7.39 | 7.01 | 7.37 | | PaO2 (mmHg) | 83-108 | | 76 | 78 | 81 | 48 | 64 | | PaCO2 (mmHg) | 35-48 | | 37 | 40 | 38 | 104 | 36 | | BE (mmol/L) | -3.0-3.0 | | 2.3 | 1.8 | 1.3 | -7.3 | -4.1 | | D-dimer (ng/mL) | <550.0 | 586.2 | 690.2 | 780.1 | | 890.5 | 900.4 | | NT-proBNP (pg/mL) | <900.0 | 308.8 | 1169.5 | 1208.2 | | 2230.4 | 2508.5 | | WBC (×109/L) | 3.50-9.50 | 7.52 | 18.8 | 19.3 | 21.4 | 22.6 | 20.5 | | Neu (%) | 45.0-75.0 | 71.8 | 88.2 | 89.8 | 89.6 | 90.1 | 89.8 | | RBC (×1012/L) | 3.80-5.10 | 4.0 | 3.98 | 3.91 | 3.82 | 3.56 | 3.81 | | Platelet (×109/L) | 100-300 | 149 | 100 | 105 | 98 | 91 | 89 | | CRP (mg/L) | <10 | <5.0 | 15.03 | 20.0 | 23.26 | 24.00 | 26.80 | | ESR (mm/h) | <20 | 12 | 30 | 38 | | | 57 | | PCT (ng/mL) | <0.0500 | 0.0100 | 0.18 | | 0.20 | | 0.04 | | Free T3 (pmol/L) | 3.1-6.8 | 3.8 | 3.3 | | | | | | Free T4 (pmol/L) | 9.5-24.5 | 13.3 | 16.1 | | | | | | TSH (μIU/mL) | 0.35-5.00 | 2.56 | 2.75 | | | | |
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ICI: immune checkpoint inhibitor; TnI: troponin I; CK-MB: creatine kinase MB; CK: creatine kinase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; K: potassium; Mg: magnesium; Scr: serum creatinine; GFR: glomerular filtration rate; PaO2: partial pressure of arterial oxygen; PaCO2: partial pressure of arterial carbon dioxide; BE: base excess; NT-proBNP: N-terminal pro-brain natriuretic peptide; WBC: white blood cell; Neu: neutrophil; RBC: red blood cell; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; PCT: procalcitonin; T3: triiodothyronine; T4: hyroxine, TSH: thyroid-stimulating hormone.
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