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Case Reports in Critical Care
Volume 2015, Article ID 198570, 2 pages
Case Report

Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome

1Division of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, Italy
2Division of Cardiology, Department of Advanced Biomedical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, Italy

Received 25 September 2014; Revised 19 January 2015; Accepted 23 January 2015

Academic Editor: Gerhard Pichler

Copyright © 2015 Francesco Raimondi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Persistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary valve and vascular tree but a  mmHg. The infant promptly responded to inhaled nitric oxide while on mechanical ventilation and was later shifted to oral sildenafil. It is not clear whether our observation may be due to direct viral damage to the endothelium or to the rubella virus increasing the vascular tone via a metabolic derangement.