Flucytosine Pharmacokinetics in a Critically Ill Patient Receiving Continuous Renal Replacement Therapy

Table 1

Flucytosine dosing recommendations in renal impairment^a  [3, 5, 8–10].

Flucytosine dosing of 100 mg/kg/day (normal renal function)		Flucytosine dosing of 150 mg/kg/day (normal renal function)
CrCL (mL/min)	Dose	CrCL (mL/min)	Dose
>50	25 mg/kg every 6 hours	>40, >50	37.5 mg/kg every 6 hours
10–50	25 mg/kg every 12–24 hours	20–40, 10–50	37.5 mg/kg every 12–24 hours
<10	25 mg/kg every 24–48 hours	<20, <10	37.5 mg/kg every 24–48 hours
Hemodialysis	Single, supplemental doses of 20–50 mg/kg after dialysis sessions	Hemodialysis	Single, supplemental doses after dialysis sessions
CRRT	No specific recommendations	CRRT	CVVHD/CVVH: 37.5 mg/kg every 12–24 hours

CrCL: creatinine clearance, CRRT: continuous renal replacement therapy, and CVVHD/CVVH: continuous venovenous hemodialysis/continuous venovenous hemofiltration.