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Case Reports in Critical Care
Volume 2016 (2016), Article ID 5232804, 4 pages
http://dx.doi.org/10.1155/2016/5232804
Case Report

Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone

1Department of Internal Medicine, University of Kentucky, Lexington, KY, USA
2Department of Internal Medicine, Jersey City Medical Center, Jersey City, NJ, USA

Received 13 May 2016; Revised 20 August 2016; Accepted 23 August 2016

Academic Editor: Tuuli Metsvaht

Copyright © 2016 Robin Paudel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication. The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form.