Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor

Table 1

Changes in haematological and biochemical parameters during the course of the disease.

Parameter	Day 1	Day 6	Day 7	Day 8	Day 11	Day 13	Day 69
Haemoglobin (115–165 g/L)	119	77	104	82	95	88	91
Platelets (150–450)	251	113	170	136	23	29	404
INR (<1.3)	1.8	1.7	1.7	2	1.8	1.8	1.3
APTT (26–36 seconds)	53	41	39	49	40	107	28
Urea (3–10 mmol/L)	18.4	8.7	12.8	11.2	12	9.1	11
Creatinine (40–80 micromol/L)	480	143	173	93	75	48	88
Estimated GFR (>60 mL/min/1.73 m^2)	7	31	25	52	68	90	55
Total bilirubin (<15 micromol/L)	53	108	157	156	167	163	10
ALT (0–30 units/L)	746	1094	1605	1537	1228	1346	30
AST (<35 units/L)	1153	1736	2591	2020	1219	890	46
GGT (<35 units/L)	527	348	399	387	234	224	134
ALP (30–115 units/L)	260	232	293	325	248	208	104
pH (7.38–7.43)	7.34	7.46	7.46	7.5	7.42	7.5	7.43
Bicarbonate (20–24 mmol/L)	11	23	15	21	22	24	34
Base excess (−3.3–1.2 mmol/L)	13.2	0.3	7.2	1.1	1.2	1.8	8.6
Lactate (0.5–2.0 mmol/L)	1.5	3.3	7.4	4.2	4.1	2.9	1.4

APTT: activated partial thromboplastin time, INR: International Normalised Ratio, and GFR: Glomerular Filtration Rate.