| Age | Young children and individuals over 65 years |
| Diseases | Dermatologic conditions, infection, and endocrine disorders that increase endogenous heat production, cardiovascular disease, obesity, dehydration, pulmonary disease, neurologic disease, psychiatric illness, and previous history of heat-related illnesses1 |
| Medicine | Beta-blockers, diuretics, calcium channel blockers, laxatives, anticholinergic drugs, salicylates, thyroid agonists, benzatropine, trifluoperazine, ephedra, certain diet pills, butyrophenones, alpha agonists, inhaled anaesthetics, monoamine oxidase inhibitors, and sympathomimetic medications |
| Drugs | Alcohol, cocaine, amphetamine, and derivatives, PCP and LSD |
| Social | Immobilization, isolation, being unable to care for oneself, low socioeconomic status, residing in upper floors in tall buildings, no air-condition at home, and being unable to secure a cooler environment for a few hours daily |
| Exposure | Prolonged sun exposure, recent move from a temperate to a hot climate, hot environments, and wearing excessive or protective clothing limiting heat dissipation |
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