Critical Care Management for Novel 2019 SARS-CoV-2 and HCoV-NL63 Coinfection in a Young Immunocompromised Patient: A Chicago Experience

Table 1

Laboratory test results.

Laboratory test	Reference values	Day 1	Day 3	Day 6	Day 9	Day 12	Day 15	Day 18	Day 21	Day 24	Day 25
White blood cells (×10^9/L)	4.2-11	11.9	18.9	12.5	11.1	13.1	15	20.4	22.8	19.8	20.1
Absolute neutrophiles (×103)	1.8-7.7	11.1	18	11.8	9.8	12.2	13.7	19	20.1	17.4	16.8
Absolute lymphocytes (×10^3)	1.4-4.0	0.5	0.6	0.5	0.9	1	0.6	1	0.7	0.6	0.4
C-reactive protein (mg/dL)	<1		30.1	17.8		10.4	3.4	8.2		1	0.5
Ferritin (ng/mL)	8-252	711	14,188	7,350	4,844	5,127	2,736	2,868	2,927	4,720	5,607
LDH (U/L)	82-240	341	693	862	811	683		715	515
Procalcitonin (ng/mL)	<0.1	11.32		3.01	3.89	1.22		1.63
Interleukin-6 (pg/mL)	≤5			16
Troponin 1 (ng/mL)	<0.05	0.1	0.46	0.07
NT-proBNP (pg/mL)	<451	30,860		18,041		22,398
Creatinine (mg/dL)	0.51-0.95	4.87	5.09	5.92	3.73	3.29	4.3	3.04	3.11	2.85	3.01
eGFR (mL/min/1.73 m^3)	>90	12	11	9	16	19	14	21	20	23	21
D-dimer (μg/mL)	<0.57	1.08			14.52	8.23	5.85			3.74	4.42
AST (U/L)	<38	22		59		45	45	82	51	480	264
ALT (U/L)	<64	43		75		17	21	49	72	368	373
Total bilirubin (mg/dL)	0.2-1.0	0.2				0.2	0.2	0.3	0.3	3	4.2
Creatine kinase (U/L)	26-192					43
Lactate (mmol/L)	0.0-2.0	2.6				1.4
Triglycerides (mg/dL)	<115			450		315		166	246	672
pH	7.35-7.45	7.31	7.32	7.36	7.37	7.37	7.33	7.37	7.38	7.38	7.26
PaCO2 (mmHg)	32-45	31	37	33	46	50	47	46	41	34	37
PaO2 (mmHg)	83-108	66	97	72	64	73	60	77	76	63	83
PaO2 to FiO2 ratio	300-500	66	162	120	128	122	86	110	126	157	165
PEEP		12	12	10	12	15	15	18	18	12	10
FiO2 (%)		100	60	60	50	60	70	70	60	40	50
(1,3)-beta-D-glucan (pg/mL)								138(+)
HCoV-NL63		+
Novel 2019 SARS-CoV-2		+

eGFR: estimated glomerular filtration rate; AST: aspartate aminotransferase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; PaCO₂: partial pressure of carbon dioxide; PaO₂: partial pressure of oxygen; FiO₂: fraction of inspired oxygen; O₂ sat: oxygen saturation; PEEP: positive end-expiratory pressure.