Dantrolene Administration in the Management of the Prehospital Patient with Methylenedioxymethamphetamine Overdose: A Case Series and Literature Review
Table 1
All patient data for dantrolene administration, body temperatures, serum creatinine, serum sodium, serum AST, serum ALT, serum troponin, serum CPK, evidence of seizures, evidence of end-organ damage, number of organs affected, and mortality.
Patient
Dantrolene (yes/no)
Temp (F) in field
Temp (F) ED arrival
Cr (mg/dL)
Sodium (mEq/L)
AST (U/L)
ALT (U/L)
Troponin (U/L)
CPK (U/L)
Seizure (yes/no)
End-organ damage (yes/no)
Number of organs affected
Mortality
Patient 1
Yes
106
99.5
1.7
138
44
48
<0.3
664
No
Yes
1
None
Patient 2
No
108
102.9
2.7
144
79
19
0.63
65730
No
Yes
3
None
Patient 3
Yes
106
95.7
2.4
137
195
293
2.27
1311
Yes
Yes
4
None
Patient 4
Yes
108
104
2.2
130
413
512
0.95
41262
No
Yes
4
None
Patient 5
Yes
109
88.1
1.6
138
29
20
2.56
60669
Yes
Yes
4
None
Patient 6
No
102.6
97
1.1
138
78
52
<0.3
473
No
No
0
None
Patient 7
Yes
108.3
89.9
1.5
137
40
49
0.45
2553
No
Yes
3
None
Patient 8
Yes
107.5
93.3
1.1
137
64
40
<0.3
6408
No
Yes
1
None
Patient 9
Yes
108.3
96.1
1
133
306
296
<0.3
11332
No
Yes
2
None
Legend: F: Fahrenheit; mEq/L: milliequivalents per liter; mg/dL” milligrams per deciliter; U/L: units per liter; Cr: creatinine; AST: aspartate transaminase; ALT: alanine transaminase; CPK: creatine phosphokinase.
