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Case Reports in Dentistry
Volume 2013, Article ID 879792, 5 pages
Case Report

Inflammatory Myofibroblastic Tumor of the Lung and the Maxillary Region: A Benign Lesion with Aggressive Behavior

1Department of Oral and Maxillofacial Surgery, Cabueñes Hospital, 33394 Gijón, Spain
2Department of Oral and Maxillofacial Surgery, Central University Hospital, 33306 Oviedo, Spain
3Department of Pathology, Central University Hospital, 33306 Oviedo, Spain
4Italy Health Sciences Department, Maxillofacial Surgery Unit, University of L’Aquila, 67100, Italy
5Oral and Maxillofacial Surgery, Dental School, University of Oviedo, Catedrático José Serrano Street, 33009 Oviedo, Spain

Received 9 January 2013; Accepted 14 February 2013

Academic Editors: M. A. Qudeimat and S. R. Watt-Smith

Copyright © 2013 Lorena Gallego et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammatory myofibroblastic tumor (IMT) is a rare mass-forming lesion characterized by fibroblastic or myofibroblastic spindle cell proliferation with varying degrees of inflammatory cell infiltration. Although it has been reported in virtually every organ in the body, the lung is the most common site of involvement. Extrapulmonary IMTs, although rare, have been reported and are characterized by different, more aggressive behavior. We report an extremely rare case of maxillary metastases of pulmonary IMT. Lung IMT was initially misdiagnosed, and oral lesion mimicked clinically and radiologically a radicular cyst. On histologic examination, cells exhibited diffuse and intense immunoreactivity for α-smooth muscle actin and vimentin whereas both pulmonary and oral IMTs presented absence of cellular atypia and lack of expressivity of oncogenic determinants. Distant metastases of lung IMT are extremely unusual, and this is the first report to our knowledge with this particular clinical course. Despite the possibility that the present case could also represent a metachronous multifocal IMT, with pulmonary and extrapulmonary lesions, similar histopathological and immunohistochemical patterns in lung and maxillary region suggest a metastatic course.