Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Dentistry
Volume 2014, Article ID 137621, 5 pages
http://dx.doi.org/10.1155/2014/137621
Case Report

Clinical and Genetic Analysis of a Nonsyndromic Oligodontia in a Child

1School of Dentistry, Universidade Veiga de Almeida, 20271-020 Rio de Janeiro, RJ, Brazil
2Clinical Research Unit, Universidade Federal Fluminense, 20271-020 Niterói, RJ, Brazil
3Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil
4Department of Specific Formation, School of Dentistry, Universidade Federal Fluminense, 28625-650 Nova Friburgo, RJ, Brazil

Received 18 June 2014; Revised 10 August 2014; Accepted 12 August 2014; Published 25 August 2014

Academic Editor: Wasiu L. Adeyemo

Copyright © 2014 Orlando Lopes Coelho Neto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The etiology of tooth agenesis may be related to several factors, among them, the genetic alterations that play a fundamental role in the development of this dental anomaly, so that knowledge about it helps the clinician to have a greater understanding of their patients. Thus, the aim of this study was to report the case of a nonsyndromic child, with tooth agenesis of one premolar, three first permanent molars, and all second permanent molars. In addition, a genetic research between polymorphic variants in genes MMP3 and BMP2 was performed in order to observe the association between changes in these genes and congenital tooth absences. For this purpose, DNA from child was extracted and polymorphisms were investigated. It was clinically and radiographically observed that this was a case of oligodontia, in which the authors suggested an association between the polymorphisms found and tooth agenesis diagnosed in that child.