Case Reports in Dentistry / 2014 / Article / Tab 1

Case Report

Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta

Table 1

Classification of osteogenesis imperfecta into the four most frequent types.

Types**Main features

Type IAMild absence of bone deformity
Caused by mutations in COL1A1 or COL1A2
Affects approximately 60–70% of carriers of OI
Blue sclerae
Normal stature

Type IBDentinogenesis imperfecta associated with type IA

Type IIMore severe form
High antenatal mortality rate due to extreme bone fragility

Type IIIAPresence of progressive bone deformities and short stature
Presence of extreme ligamentous laxity
Affects approximately 20% of carriers of OI

Type IIIBDentinogenesis imperfecta associated with type IIIA

Type IVAMild deformities with variable degrees of short stature
Diversified form
Blue and white-grayish sclerae
Associated hearing loss
Mutations in COL1A1 or COL1A2
Affects approximately 10% of carriers of OI

Type IVBDentinogenesis imperfecta associated with type IVA

*Modified from Sillence et al. [14].
**Additional subtypes: I-A and I-B (Levin et al. [15]); III-A and III-B (adopted in the present study); IV-A and IV-B (Paterson et al. [16]).
Footnote. OI may also be classified into types V (Glorieux et al. [17]), VI (Glorieux et al. [18]), VII (Ward et al. [19]), and VIII (Cabral et al. [20]) based on clinical and bone histological parameters.