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Case Reports in Dentistry
Volume 2014 (2014), Article ID 860804, 5 pages
http://dx.doi.org/10.1155/2014/860804
Case Report

Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin

1Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
2Special Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil
3Department of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
4Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil
5Neurology Service, Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil

Received 8 July 2014; Accepted 18 September 2014; Published 15 October 2014

Academic Editor: Márta Radnai

Copyright © 2014 Jôice Dias Corrêa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts. In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation.