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Case Reports in Dentistry
Volume 2016, Article ID 4803167, 8 pages
Case Report

Hypophosphatemic Rickets in Siblings: A Rare Case Report

Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India

Received 29 October 2015; Accepted 6 April 2016

Academic Editor: Yousef S. Khader

Copyright © 2016 Gummadapu Sarat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypophosphatemic rickets (HR) is a type of hereditary rickets characterized by persistent hypophosphatemia and hyperphosphaturia. The most predominant type is inherited in an X-linked fashion and caused by mutation in the gene encoding the phosphate-regulating endopeptidase homolog, X-linked (PHEX), identified in 1995. The X-linked hypophosphatemic (XLH) rickets is a rare hereditary metabolic disorder with a prevalence of 1 in 20,000 and causes deficient calcification of mineralized structures such as bones and teeth resulting in dental problems in terms of delayed eruption, spontaneous periapical infections, and exfoliation. We report one such unique case of hypophosphatemic vitamin D-resistant rickets in siblings exhibiting classical features of rickets with emphasis on its treatment and dental considerations.