A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism

Figure 3

Central giant-cell granuloma (CGCG). (a) A lobulated mass of proliferating connective tissue containing many giant cells. (b) A larger view of the giant cell containing more than ten nuclei each. (c) Ki-67 indicates a low mitotic index. The lesion is defined as locally aggressive but cannot be considered as a true neoplasm. (d) CD68 antibody indicates the giant cells deriving from the monocytic-macrophagic line. (e) The so-called “cannibal cells” (arrows) indicate an aggressive CGCG and could suggest likely recurrence. (f) A larger view of the monocytic-derived cannibal giant cells highlighted with CD68.

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