Case Reports in Dentistry

Case Report

A Case of Buccal Clear Cell Carcinoma Caused by Rare Fusion Gene: EWSR1-CREM

Table 1

Clinical features and staining patterns of previously reported cheek or buccal mucosa CCC cases.
AuthorsYearAgeSexSize (cm)MetastasisImmunohistochemical stainingSpecial stainingFusion typeTreatmentRecurrenceFollow-up and outcome
CKp63CD10S100α-SMAKi-67PASd-PASMCALC
Simpson et al. [14]199066M2.5—+NANA—NANANANANANANASur—NED (11 y)
Hiroki et al. [15]199930F3—+NANA—NANA+NANA—NASur—NED
Milchgrub et al. [16]200029F2+†NANANANANANANANANANANASur+REC (12 mo)
O’Sullivan-Mejia et al. [17]200978F1.7—+—NANANANA+NA—NANASur—NED
Solar et al. [9]200949F3NA+NANA——NA+——NANASur+REC × 2 (114 mo)
Onoda et al. [11]201259F0.8—+————NA+—NA—NASur—NED (4 y)
Shah et al. [18]201346FNA+†++NA——NANANANANAEWSR1 reRad, RS+NA
201337FNA+†++NA——NANANANANAEWSR1 reSur+NA
Yamanishi et al. [3]201552F1.5—++NA——NANANA—NAEWSR1-ATF1Sur—NED (11 y)
Albergotti et al. [19]201670F4.9—NANANANANANANANANANAEWSR1 reSur—NED (13 mo)
Hernandez-Prera et al. [20]201757F2—NA+NA——NANANA—NAEWSR1-ATF1Sur—NED (24 mo)
Present study202069F1.5—++———±+———EWSR1-CREMSur—NED (2 y)
NA: not available or not mentioned; NED: no evidence of disease; REC: recurrence; MC: mucicarmine; ALC: Alcian blue; re: rearrangement; Rad: radiotherapy; RS: reduction surgery; Sur: surgery. †Cervical lymph nodes.