Case Report

Medication-Related Osteonecrosis of the Jaw Spontaneously Occurred in a Patient with Chronic Myelogenous Leukemia Only by Imatinib: A Report of a Rare Case

Table 1

Reported MRONJ cases related to imatinib [17ā€“19].

No.Study (yr)Age (yr)/genderDiseasePeriod of imatinib treatment (mo)Antiresorptive agentTrigger eventStageTreatmentClinical outcome

1Nicolatou-Galitis et al. (2013) [17]71/MCML19Alendronate
Zoledoronate
Denosumab
Tooth extractionIIAntibioticImproved
2Viviano et al. (2017) [19]72/MGIST22NoneTooth extractionIIAntibioticUnknown
3Mohamed et al. (2018) [18]81/FCLL13Alendronate
Denosumab
Tooth extractionIISurgeryHealed
4Present case (2020)52/FCML111NoneNoneIISurgeryHealed

Abbreviations: MRONJ: medication-related osteonecrosis of the jaw; F: female; M: male; CML: chronic myelogenous leukemia; GIST: gastrointestinal stromal tumor; CLL: chronic lymphocytic leukemia.