Case Reports in Dentistry

Case Reports in Dentistry / 2021 / Article

Case Report | Open Access

Volume 2021 |Article ID 9940304 | https://doi.org/10.1155/2021/9940304

Mohammad Jafarian, Fatemeh Mashhadi Abbas, Mitra Ghazizadeh Ahsaie, Homeira Saebnoori, "Clinical, Imaging and Histopathology of Angioleiomyoma of the Buccal Cheek", Case Reports in Dentistry, vol. 2021, Article ID 9940304, 11 pages, 2021. https://doi.org/10.1155/2021/9940304

Clinical, Imaging and Histopathology of Angioleiomyoma of the Buccal Cheek

Academic Editor: Giovanni Mergoni
Received06 Mar 2021
Accepted22 Apr 2021
Published30 Apr 2021

Abstract

Angioleiomyoma is a benign neoplasia originating from vascular smooth muscle and very uncommon in the oral cavity. In this report, we present a rare case of angioleiomyoma in oral cavity in a 46-year-old female buccal cheek and discuss the clinical, histological, and immunohistochemical characteristics. As the treatment of choice is the complete excision, the lesion was excised under local anesthesia with no further complications. In addition, a brief update on other reported cases of angiomyoma in the oral cavity is further discussed.

1. Introduction

Angiomyoma or angioleiomyoma (also known as vascular leiomyoma) are benign neoplasms originating from vascular smooth muscle [1, 2]. Histologically, there are subgroups in three categories: solid, venous, and cavernous [3]. They commonly occur in the extremities and female genital tract and rarely in the oral cavity [4, 5]. The most common site in the oral cavity is in the lips [1]. Other reported sites were the palate, tongue, cheek, gingiva, retromolar area, and submandibular triangle [2, 610]. Although the etiology is still unclear, previous studies report trauma or spontaneous development as the causes of origin in oral cavity [10, 11]. The lesion is most often detected in adults of 30 to 50 years old [3]. Clinically, it usually presents as a slow growing, painless nodule or mass of variable size; however, pain has also been reported [12]. The final treatment and diagnosis is based on surgical excision and hematoxylin and eosin (H&E) staining and immune-histochemical (IHC) assessments [1]. In this report, a rare case of angioleiomyoma in the cheek along with a complete imaging assessment including color Doppler ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) with an update on the literature is presented.

2. Case Report

A 46-year-old female was referred to a private clinic of an Oral and Maxillofacial Surgeon with complaint of a painless swelling in the right side of her cheek since 6 years ago. The swelling was initially small in size and slowly enlarged, although the patients faced no tenderness in the area. The patient had diabetes mellitus and anemia. In addition, no history of previous trauma to the area was present. Extraoral examination showed no asymmetry or marked expansion on the right cheek. On intraoral examination, no clinically visible lesion was detected. The mucosa was intact with no color change. When the area was palpated, a firm, compressible solid mass was detected with moderate attachment to the adjacent tissues. The estimated size of the lesion was , and the approximate diameter was 1.5 cm. No pulsation or bruit was present. The patient had previously visited and had prior imaging including Doppler ultrasonography, multidetector computed tomography (MDCT), and MRI. The results of ultrasonography indicated a well-defined hypoechoic heterogeneous mass lying beneath the skin measuring (Figure 1). The lesion had moderate vascular flow. MDCT showed a circular well-defined homogenous mass over the buccinator muscle (Figure 2). The MRI T1 sequence showed a well-defined low signal mass between the buccinator muscle and buccal fat (Figure 3(a)). The MRI T2 sequence showed that the mass is homogenous and high signal (Figure 3(b)). A soft tissue mass was suspected, and an intraoral surgical excisional biopsy was planned. Upon obtaining consent, an excisional biopsy was performed under local anesthesia and incision was made on the buccal mucosa just over the palpated mass (Figure 4). The lesion was completely excised (Figure 5). H&E staining histopathological examination demonstrated an encapsulated mass composed of fully developed cavernous angioma in a fibrous stroma and occasionally myxomatous change. The thin-wall blood vessels showed papillary projections to the lumen which some had become irregular, large in size, and even sinusoid in some areas (Figure 6(a)). The stroma contains immature spindle-shaped fibroblasts with a paralleling fascicle pattern next to the blood vessels (Figure 6(b)). The mixed inflammatory infiltration and hyalinized area intermixed with adipose tissue were also found. In the IHC staining analysis, the specimen was positive for both SMA (smooth muscle actin) (Figures 7(a) and 7(b)) and desmin (Figures 7(c) and 7(d)); however, the microscopic features in combination with IHC findings were consistent with angioleiomyoma diagnosis. A postoperative follow-up of the patient was uneventful. The area had healed with no complication, and no signs of recurrence were detected.

3. Discussion

Angioleiomyoma is a rare benign soft tissue neoplasm of oral cavity [7]. Although hormonal changes, trauma, and venous stasis are suggested as possible causes, the etiology is still unknown [5]. On our latest review of literature from year 2000 to 2020 using the PubMed Central search engine, 25 articles (32 cases) were retrieved (Table 1). The most common sites of oral angiomyomas were the lip [2, 4, 1215], cheek or buccal mucosa [5, 8, 14, 1618], palate [7, 1921], tongue [6, 22, 23], and submandibular area [9, 11, 24]. The gingiva [10], mandible [2], retromolar area [2], and anterior maxillary labial fold [17] were each reported once among the studies. 73% of patients were male, and 27% were females, which is consistent with previous studies [25, 26]. The mean age was years old (range 2 to 79). Only one study reported a congenital angiomyoma in the tongue [3]. In all reviewed studies, the patient faced a painless swelling. Only three cases reported pain associated with the lesion [7, 21, 24].


NoAuthor & yearAge & sexLocationSizeSign & symptomsRadiologic assessmentsTreatment planAnesthesiaHistologic assessmentsFollow-up

1Mehta et al., 2020 [15]57 YO, MLower lipExophytic nodular swellingSurgical excisionLocalH&E:
Large vascular channels of varying caliber, surrounded by thick walls of irregularly arranged spindle-shaped cells. Whorled bundles of muscle fibers were seen fused with the vessel walls
IHC:
SMA+
3 Mo, no recurrence
2Giudice et al., 2019 [32]17 YO, FCheekSwellingSurgical excisionLocalH&E:
Uniform spindle smooth muscle cells with pale eosinophilic cytoplasm, low amount of fibrous connective tissue, and distributed around numerous small tortuous “slit-like” vessels
IHC:
SMA+
CD34+
Desmin+
Vimentin+
1 week, 4 weeks, 6 months
No recurrence
3Pandya et al., 2019 [23]46 YO, FPalateExophytic growth, painOcclusal plain filmSurgical excisionLocalH&E:
Numerous thick-walled blood vessels in the connective tissue formed of hyperplastic smooth muscle fibers
IHC:
SMA+
6 Mo, no recurrence
4Perić et al., 2019 [4]36 YO, MLipPainless swellingSurgical excisionLocalH&E:
Numerous thick-walled vessel
IHC:
CD34+
SMA+
7 D, normal healing
5Ribeiro et al., 2019 [18]60 YO, MAnterior maxillary labial foldSwellingSurgical excisionH&E:
Multiple vessels, thickened muscular layer
IHC:
CD34+
SMA+
2 Y, no recurrence
6Ribeiro et al., 2019 [18]33 YO, MBuccal mucosaSubmucosal noduleColor Doppler ultrasonography: well-limited hyperechoic area between cutaneous and muscular layers, no change in blood flowSurgical excisionH&E:
Multiple vascular spaces of various sizes and calibers, sometimes congested and interconnected
IHC:
CD34-
SMA+
7S.Y. Rawal and Y.B. Rawal, 2018 [22]70 YO, MHard palatePainless massSurgical excisionH&E:
Brightly eosinophilic, spindle-shaped cells
IHC:
SMA+
8Hassona et al., 2017 [14]52 YO, FUpper lipPainless massSurgical excisionLocalH&E:
Vascular channels surrounded by fascicles of concentrically arranged spindle cells with eosinophilic cytoplasm
IHC:
SMA+
12 Mo, no recurrence
9Osano et al., 2015 [5]45 YO, MCheekPainless massMRI:
T1+contrast: homogeneously enhanced mass and a vessel leading to the tumor
T2:
Uniform signal and hyperintense signal
Surgical excisionGeneralH&E:
Proliferation of vessels with a smooth muscle wall and vessels surrounded by smooth muscle cells
IHC:
SMA+
Desmin+
Vimentin+
18 Mo, no recurrence
10Ishikawa et al., 2014 [6]51 YO, MTongue11 mmNodular massSurgical excisionH&E:
Brightly eosinophilic, spindle-shaped cells
IHC:
SMA+
HHF-35 actin+
Vimentin+
Desmin+
S100-
CD34-
8 Mo, no recurrence
11Tsuji et al., 2014 [7]79 YO, MHard palatePainless swellingPanoramic:
No source of odontogenic infection
CT:
Well-circumscribed mass, no evidence of surrounding bone resorption
Surgical removal and curettageLocalH&E:
Vascular spaces and redundant smooth muscle
IHC:
Desmin+
SMA+
6 Mo, no recurrence
12Eley et al., 2012 [21]39 YO, MHard palate2 cmPainless swellingMRI:
T1:
Slightly higher than the surrounding soft tissue
T2:
Marked hyper intensity
Surgical excisionGeneralH&E:
Vascular channels surrounded by fascicles of spindle cells
IHC:
Desmin+
SMA+
3 Mo, no recurrence
13Minni et al., 2012 [11]54 YO, FSubmandibular spacePainless swellingMRI:
Displacement of submandibular gland, tongue, and oropharynx airway
Compressing the right tonsil
Ultrasound-guided FNA:
Blood-stained aspirate
Complete surgical removalGeneralH&E:
Smooth muscle tissue punctuated with thick-walled vessels, capillary, and venous-type vessels
IHC:
SMA+
6 Mo, no recurrence
14Menditti et al., 2012 [10]14 YO, MGingiva1-2 cmPainless swellingRadical excision with 2 mm free marginsLocalH&E:
Vascular spaces and redundant smooth muscle
IHC:
SMA+
1 Y, no recurrence
15Gueiros et al., 2011 [16]-54 YO, M
-66 YO, M
-53 YO, M
Lower lip
Upper lip
Upper lip

Painless noduleSurgical excisionLocalH&E:
Spindle-shaped cells and blood vessels
IHC:
MSA+
-2 Y
-1 Y
-6 Mo, no recurrence
16Vidaković et al., 2011 [8]58 YO, MCheekPainless swellingSurgical excisionLocalH&E:
Thick-walled vessels with partially patent and smooth muscle fibres
7 D, normal healing of wound
17Kim et al., 2010 [3]2 YO, MTongueSoft tissue massMRI:
Elevated mass on the base of the tongue
T1:
Isointense signal to muscle
T2:
Slightly hyperintense signal with hyperintense rim
Surgical removalGeneralH&E:
Prominent and thickened vessel walls consisting of benign and mature smooth muscle cells
IHC:
Desmin+
SMA+
26 Mo, no recurrence
18Nonaka et al., 2010 [25]38 YO, MTongue2 cmPainless exophytic massSurgical excisionH&E:
Proliferation of spindle-shaped nucleus cells, numerous blood vessels
IHC:
SMA+
1 Y, no recurrence
19Keerthi et al., 2009 [17]32 YO, MCheekPainless swellingCT:
Large nonhomogenously enhancing mixed density lesion in the infratemporal fossa and the buccal space, moderately enhancing soft tissue component superolaterally, with no calcification or necrosis
Surgical removalGeneralH&E:
Multiple blood vessels with proliferation of smooth muscle
6 Y, no recurrence
20Keerthi et al., 2009 [17]32 YO, MCheekPainless swellingPlain film radiograph:
No bony changes
Ultrasound:
Hypoechoic lesion more in favor of soft tissue swelling
Surgical removalGeneralH&E:
Spindle-shaped fascicles and many blood vessels
IHC:
Masson trichrome stain (+)
1 Y, no occurrence
21McParland et al., 2009 [19]42 YO, MBuccal mucosalPainless swellingSurgical excisionLocalH&E:
Smooth muscle bands are surrounded by slit-like vascular spaces
6 Mo, no recurrence
22Cepeda et al., 2008 [2]39 YO, F
27 YO, F
43 YO, F
36 YO, M
48 YO, M
Retromolar area
Mandibular region
Lower lip
Upper lip
Upper lip




Painless massRoutine radiographic inspection:
A unilocular radiolucency located in a mandibular region (in case 2)
Surgical excisionH&E:
Several blood vessels lined by a thin layer of endothelial cells were observed intercalated in the fascicules
IHC:
SMA+
Vimentin+
Desmin+
CD34-
23Manor et al., 2007 [20]39 YO, MBuccal vestibule8Asymptomatic massCT:
Hypervascular soft tissue mass, with no invasion of the periosteum or bone
Surgical excisionH&E:
Bands of smooth muscle cells surrounding multiple vascular spaces of varying size
IHC:
SMA+
12 Mo, no recurrence
24Ide et al., 2003 [26]40 YO, FSubmandibular glandPainful swellingSurgical excisionH&E:
Tortuous thick-walled vessels in varying sizes, proliferation of smooth muscle
IHC:
SMA+
CD31–
CD34–
S-100-
25Toida et al., 2000 [12]10 YO, MLower lipPainful massSurgical excisionLocalH&E:
Spindle cells surrounded by numerous slit-like vessels
IHC:
SMA+
S-100-
3 Y, no recurrence
26Simon et al., 2000 [9]59 YO, FSubmandibular triangleNontender massColor Doppler ultrasound:
Well-circumscribed, homogeneous solid mass attached to the posterior surface of the submandibular gland, vascularity within the mass
Surgical excisionGeneralH&E:
Smooth muscle punctuated with thick-walled venous vascular channels

Preoperative radiologic assessments varied among the studies, from no radiographic assessments and plain radiography to ultrasound, MRI, and CT evaluations. To our knowledge, this is the first case report of angioleiomyoma with a thorough imaging assessment including color Doppler sonography, MDCT, and MRI. The lesion was slightly heterogeneous hypoechoic mass with slight vascular flow in the color Doppler sonography; in addition, the T1-weighted and T2-weighted sequences were low and high, respectively. The high T2-weighted sequence may be seen in cysts, benign or low-grade minor salivary gland tumors, and rare hemangiomatous lesions [27]. In this case, differential diagnosis such as benign lesions of salivary gland origin was suggested in lower possibility because the lesion was located between the buccinator muscle and skin. Cystic lesions were also excluded as the sonography of the cyst is homogenous and unechoic [28]. Differential diagnosis may suggest other benign mesenchymal tumors such as fibroma, lipoma, and neurofibroma and vascular lesions including arteriovenous malformation, lymphangioma, and hemangioma. However, these lesions may have different radiographic and imaging characteristics. According to previous studies, the intraosseous angioleiomyomas are radiographically unilocular or multilocular radiolucent lesions. They can have either an ill-defined or a well-defined sclerotic border [2, 11].

In this case, H&E histologic examination showed a tumor consisting of thin- and thick-walled blood vessels in a background of smooth muscle proliferation. Having numerous blood vessels may pretend other benign vascular tumors such as hemangioma, hemangiopericytoma, hemangioendothelioma, vascular malformation, and other neurovascular hamartomas [29], but a definite examination could rule out these lesions because of the smooth muscle background. Immunohistochemically markers like SMA and MSA (muscle-specific actin) can be useful in identification of smooth muscle nature of the cellular stroma [15, 30, 31]. In the present study, IHC staining was positive for both desmin and SMA. Various IHC stainings were carried out among studies (Table 1) although SMA and desmin were the most frequent. Depending on the apparent features of the blood vessels, IHC staining of endothelial cell markers such as CD34 and CD31 was not recommended. Other differential diagnosis histopathologically is leiomyosarcoma if there were more cellular pleomorphism and mitosis figures. In addition to well circumscribing of this tumor, lacking of anaplasia and bizarre cells, fewer than 5 mitoses per 20 high-power fields could rule out sarcoma.

In all evaluated cases, the lesion was resected with an excisional biopsy under local or general anesthesia. There are no recurrences after resection.

4. Conclusion

In conclusion, we have reported a case of angioleiomyoma of the buccal cheek that resulted in a good outcome. Among various studies, the most common sites of oral angiomyomas were the lip [2, 4, 1215, 32], cheek or buccal mucosa [5, 8, 14, 1618], palate [7, 1921], tongue [6, 22, 23], and submandibular area [9, 11, 24]. Other areas such as the gingiva, mandible, retromolar area, and anterior maxillary labial fold were only reported once among studies [2, 10, 17]. Due to the benign nature of this lesion, the treatment is excisional biopsy and there have been no recurrences or complications reported so far [32].

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. J. Aitken-Saavedra, K.-D. da Silva, A.-C. Ana-Paula-Neutzling Gomes, U. Vasconcelos, A. Etges, and T.-G. Nóbrega, “Clinicopathologic and immunohistochemical characterization of 14 cases of angioleiomyomas in oral cavity,” Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 23, no. 5, p. e564, 2018. View at: Google Scholar
  2. L. G. Cepeda, D. Q. Rivera, F. T. Rocha, E. Huerta, and E. Sanchez, “Vascular leiomyoma of the oral cavity. Clinical, histopathological and immunohistochemical characteristics. Presentation of five cases and review of the literature,” Medicina Oral, Patología Oral y Cirugía Bucal, vol. 13, no. 8, pp. e483–e488, 2008. View at: Google Scholar
  3. Y. Kim, Y. Jang, H. Pai, and S. Kim, “Congenital angiomyoma of the tongue: case report,” Dentomaxillofacial Radiology, vol. 39, no. 7, pp. 446–448, 2010. View at: Publisher Site | Google Scholar
  4. B. Perić, B. Vidaković, N. Grgić, S. Manojlović, and H. Čavka, “Angiomyoma of the upper lip–case report and review of the literature,” Acta Clinica Croatica, vol. 58, no. 1, pp. 183–186, 2019. View at: Google Scholar
  5. H. Osano, Y. Ioka, R. Okamoto et al., “Angioleiomyoma of the cheek: a case report,” Journal of Oral Science, vol. 57, no. 1, pp. 63–66, 2015. View at: Publisher Site | Google Scholar
  6. S. Ishikawa, S. Fuyama, T. Kobayashi, Y. Taira, A. Sugano, and M. Iino, “Angioleiomyoma of the tongue: a case report and review of the literature,” Odontology, vol. 104, no. 1, pp. 119–122, 2016. View at: Publisher Site | Google Scholar
  7. T. Tsuji, K. Satoh, H. Nakano, and M. Kogo, “Clinical characteristics of angioleiomyoma of the hard palate: report of a case and an analysis of the reported cases,” Journal of Oral and Maxillofacial Surgery, vol. 72, no. 5, pp. 920–926, 2014. View at: Publisher Site | Google Scholar
  8. B. Vidaković, A. Kotarac Knežević, S. Manojlović, and G. Knežević, “Angiomyoma–angioleiomyoma of the cheek,” Collegium Antropologicum, vol. 35, no. 1, pp. 207–209, 2011. View at: Google Scholar
  9. K.-H. W. Simon, A. Ahuja, J. Chow, and W.-K. K. Walter, “Angioleiomyoma in the submandibular region: an unusual tumor in an unusual site,” Otolaryngology—Head and Neck Surgery, vol. 122, no. 1, pp. 144-145, 2000. View at: Publisher Site | Google Scholar
  10. D. Menditti, L. Laino, L. Nastri, U. Caruso, and P. Fiore, “Oral angioleiomyoma: a rare pathological entity,” In Vivo, vol. 26, no. 1, pp. 161–163, 2012. View at: Google Scholar
  11. A. Minni, A. De Carlo, R. Roukos, G. Illuminati, and B. Cerbelli, “Angioleiomyoma of the oral cavity extended to submandibular space; an unusual tumor in an unusual deep-seated space: a case report,” European Review for Medical and Pharmacological Sciences, vol. 16, no. 4, pp. 134–137, 2012. View at: Google Scholar
  12. M. Toida, H. Koizumi, and K. Shimokawa, “Painful angiomyoma of the oral cavity: report of a case and review of the literature,” Journal of Oral and Maxillofacial Surgery, vol. 58, no. 4, pp. 450–453, 2000. View at: Publisher Site | Google Scholar
  13. P. Ramesh, S. Annapureddy, F. Khan, and P. Sutaria, “Angioleiomyoma: a clinical, pathological and radiological review,” International Journal of Clinical Practice, vol. 58, no. 6, pp. 587–591, 2004. View at: Publisher Site | Google Scholar
  14. Y. Hassona, F. Sawair, and C. Scully, “Angioleiomyoma of the upper lip,” Case Reports, vol. 2017, p. bcr-2016-219172., 2017. View at: Google Scholar
  15. P. D. Mehta, N. Desai, K. Makwana, and Y. Patel, “Angioleiomyoma of the lower lip,” Annals of Maxillofacial Surgery, vol. 10, no. 1, pp. 251–253, 2020. View at: Publisher Site | Google Scholar
  16. L.-A. Gueiros, M.-J. Romañach, A.-M. Pires-Soubhia, F.-R. Pires, O. Paes-de-Almeida, and P.-A. Vargas, “Angioleiomyoma affecting the lips: report of 3 cases and review of the literature,” Medicina Oral, Patología Oral y Cirugía Bucal, vol. 16, no. 4, pp. e482–e487, 2011. View at: Google Scholar
  17. R. Keerthi, M. Nanjappa, S. S. Deora, and S. Kumaraswamy, “Angioleiomyoma of cheek: report of two cases,” Journal of Maxillofacial and Oral Surgery, vol. 8, no. 3, pp. 298–300, 2009. View at: Publisher Site | Google Scholar
  18. J.-L. Ribeiro, F.-H. Costa, E. K. Ana-Sueli-Rodrigues Cavalcante, Y.-R. Carvalho, and A.-L. Anbinder, “Vascular leiomyoma in the oral cavity–report of two cases,” Journal of Clinical and Experimental Dentistry, vol. 11, no. 6, article e582, 2019. View at: Google Scholar
  19. H. McParland, S. Warnakulasuriya, and R. J. Cook, “Angioleiomyoma: an unusual diagnosis for a lump in the cheek,” British Journal of Oral and Maxillofacial Surgery, vol. 47, no. 8, pp. 641-642, 2009. View at: Publisher Site | Google Scholar
  20. E. Manor, N. Sion-Vardy, M. Nash, and L. Bodner, “Angiomyoma of buccal vestibule: a rare case with a normal karyotype,” The Journal of Laryngology & Otology, vol. 121, no. 12, pp. 1210–1212, 2007. View at: Publisher Site | Google Scholar
  21. K. A. Eley, S. Alroyayamina, S. J. Golding, R. N. Tiam, and S. R. Watt-Smith, “Angioleiomyoma of the hard palate: report of a case and review of the literature and magnetic resonance imaging findings of this rare entity,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 114, no. 2, pp. e45–e49, 2012. View at: Publisher Site | Google Scholar
  22. S. Y. Rawal and Y. B. Rawal, “Angioleiomyoma (vascular leiomyoma) of the oral cavity,” Head and Neck Pathology, vol. 12, no. 1, pp. 123–126, 2018. View at: Publisher Site | Google Scholar
  23. M. Pandya, D. S. Rao, G. Mamatha, and R. G. Annigeri, “Angiomyoma–a requisite in differential diagnosis of palatal growths,” International Journal of Health Sciences, vol. 13, no. 6, p. 47, 2019. View at: Google Scholar
  24. H.-Y. Kim, S.-N. Jung, H. Kwon, W.-I. Sohn, and S.-H. Moon, “Angiomyoma in the buccal space,” Journal of Craniofacial Surgery, vol. 21, no. 5, pp. 1634-1635, 2010. View at: Publisher Site | Google Scholar
  25. C. F. W. Nonaka, K. M. A. Pereira, and M. C. D. C. Miguel, “Oral vascular leiomyoma with extensive calcification areas,” Brazilian Journal of Otorhinolaryngology, vol. 76, no. 4, p. 539, 2010. View at: Google Scholar
  26. F. Ide, K. Mishima, and I. Saito, “Angiomyoma in the submandibular gland: a rare location for a ubiquitous tumour,” The Journal of Laryngology & Otology, vol. 117, no. 12, pp. 1001-1002, 2003. View at: Publisher Site | Google Scholar
  27. T. M. Yoon, H. C. Yang, Y.-D. Choi, D. H. Lee, J. K. Lee, and S. C. Lim, “Vascular leiomyoma in the head and neck region: 11 years experience in one institution,” Clinical and Experimental Otorhinolaryngology, vol. 6, no. 3, pp. 171–175, 2013. View at: Publisher Site | Google Scholar
  28. P. M. Som and H. D. Curtin, Head and Neck Imaging E-Book, Elsevier Health Sciences, 2011.
  29. C. Whittle, A. Retamal, D. Kramer, and C. Silva, “Sonographic diagnosis of periorbital dermoid cyst,” Ultrasound Quarterly, vol. 33, no. 1, pp. 37–40, 2017. View at: Publisher Site | Google Scholar
  30. G. E. Anastassov and P. A. van Damme, “Angioleiomyoma of the upper lip: report of a case,” International Journal of Oral and Maxillofacial Surgery, vol. 24, pp. 301-302, 1995. View at: Google Scholar
  31. J. K. Brooks, N. G. Nikitakis, N. J. Goodman, and B. A. Levy, “Clinicopathologic characterization of oral angioleiomyomas,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 94, no. 2, pp. 221–227, 2002. View at: Publisher Site | Google Scholar
  32. A. Giudice, F. Bennardo, C. Buffone, Y. Brancaccio, F. M. Plutino, and L. Fortunato, “Clinical and immunohistochemical features of oral angioleiomyoma: a comprehensive review of the literature and report of a case in a young patient,” Case Reports in Dentistry, vol. 2019, Article ID 2498353, 9 pages, 2019. View at: Publisher Site | Google Scholar

Copyright © 2021 Mohammad Jafarian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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