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Case Reports in Dermatological Medicine
Volume 2012, Article ID 109632, 3 pages
Case Report

A Metastasizing Squamous Cell Carcinoma Arising in a Solitary Epidermal Nevus

1Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawara-cho, Sakyo, Kyoto 606-8507, Japan
2Department of Dermatology, Otsu Red Cross Hospital, 1-1-35 Nagara, Otsu-shi, Shiga 520-8511, Japan
3Department of Dermatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka 543-8555, Japan

Received 19 March 2012; Accepted 29 May 2012

Academic Editors: M. Curzio, J.-H. Lee, and T. Salopek

Copyright © 2012 Masami Toya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Secondary tumor rarely develops from epidermal nevus. We present a case of a metastasizing squamous cell carcinoma that developed in a solitary epidermal nevus. Case Report. An 82-years old Japanese female was presented with a red tumor on the left axilla. She reported that the tumor developed in a congenital epidermal nevus. A biopsy of the tumor showed that a well-differentiated squamous cell carcinoma (SCC) arose from the epidermal nevus. As a lymph node metastasis was found by sentinel lymph node biopsy, the patient received surgical excision of the lesion, axillary lymph node dissection, and postoperative radiation. Discussion. Secondary tumors developing in epidermal nevus are rare. To the best of our knowledge, only in two cases including the present case, SCC developed in a solitary epidermal nevus. There is no established clinical guideline for prophylactic removal of epidermal nevus. However, a biopsy should be done if a secondary malignancy is suspected in an epidermal nevus.