Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female
Figure 2
(a) H&E section, ×100 magnification showing an acute totally intraepidermal blister. At both angles of the blister, the separation is entirely intraepidermal. Stratum corneum is intact which attests the acute onset of the lesion, and no signs of regeneration can be seen. No evidence of common pathological changes that induce intraepidermal blister as acantholysis or ballooning degeneration. No inflammatory cells in or around the lesion. (b) H&E section, ×200 magnification showing epidermal separation at the level of the spinous layer. Necrotic individual keratinocytes can be seen intravesicular and at the roof of the blister (no acantholysis, no ballooning or multinuclear cells). (c) H&E section, ×400 magnification showed sparse perivascular infiltrate, and collagen bundles in the papillary dermis are separated by scanty mucin deposition.
