Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female

Table 1

Showing the different manifestations of bullosis diabeticorum described in the literature [8, 9] in comparison with our case.

Common findings in published cases of bullosis diabeticorum	Our case
Long-standing diabetes mellitus	Yes
Blisters occur spontaneously and abruptly, usually without known antecedent trauma	Yes
Lesions tend to be asymptomatic, despite mild discomfort or burning	Lesions were pruritic
Associated with neuropathy	No neuropathy
Blisters heal spontaneously within 2–6 weeks of onset	Lesion took more time to heal and were more persistent
Tense blisters	Yes
Evolve on nonerythematous or normal appearing skin	Lesions erupted on erythematous base
Mild or no scarring	Yes, depressed thin scars
Blisters typically occur on the feet or lower legs	Yes
Blisters tend to be large, size ranging from few millimetres to several centimetres	3–7 mm with no tendency to coalesce
Negative immunofluorescence: no primary immunologic abnormality exists	Yes
The blister plane may appear in a subcorneal, intraepidermal, or subepidermal location	Yes, blisters were intrepidermal
Presence of degenerative and necrotic keratinocytic	Yes
Absence of urinary uroporphyrins	Yes
Recurrence of condition is common	Yes
More in males	Our case was a female