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Case Reports in Dermatological Medicine
Volume 2014, Article ID 853038, 3 pages
http://dx.doi.org/10.1155/2014/853038
Case Report

Methylprednisolone Therapy in Acute Hemorrhagic Edema of Infancy

1Department of Pediatrics, Aarhus University Hospital, 8200 Aarhus N, Denmark
2Department of Dermatology, Aarhus University Hospital, Aarhus C, 8000 Aarhus, Denmark
3Department of Pathology, Aarhus University Hospital, Aarhus C, 8000 Aarhus, Denmark

Received 12 November 2013; Accepted 22 December 2013; Published 5 March 2014

Academic Editors: A. Firooz, J. A. Tschen, and T.-W. Wong

Copyright © 2014 Jeyanthini Risikesan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present a case of an 18-month-old boy who showed severe clinical signs indicative of acute hemorrhagic edema of infancy (AHEI) with painful purpuric skin affection primarily of the face and marked edema of the ears. The histological findings were diagnostic for leukocytoclastic vasculitis and thus met the histological criteria for AHEI. Indicative of infection as causative agent for the condition were symptoms of gastroenteritis. High-dose intravenous corticosteroids led to a fast resolution of symptoms and normalization of laboratory parameters. AHEI is usually not described as being very responsive to corticosteroids. The case presented here indicates that severe cases of AHEI can be treated with high-dose intravenous corticosteroids resulting in significant relief and shortening of the symptoms. Clinical followup showed no underlying malignancy or other severe chronic systemic diseases thus confirming earlier reports that AHEI is not associated with such conditions. The differential diagnoses with AHEI are discussed.