Paget Disease of the Vulva: Diagnosis by Immunohistochemistry

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Antigen investigated</td><td align="center">Melanoma in situ</td><td align="center">Paget disease</td><td align="center">Present case</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Melan A</td><td align="center">+</td><td align="center">−</td><td align="center">−</td></tr><tr><td align="left">S100 protein</td><td align="center">+</td><td align="center">−</td><td align="center">−</td></tr><tr><td align="left">Cytokeratins</td><td align="center">−</td><td align="center">+</td><td align="center">+</td></tr><tr><td align="left">Carcinoembryonic antigen (CEA)</td><td align="center">−</td><td align="center">+</td><td align="center">+</td></tr><tr><td align="left">Epithelial membrane antigen (EMA)</td><td align="center">−</td><td align="center">+</td><td align="center">+</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Differentiation between the immunohistochemical profile commonly found in skin melanomas and that found in Paget disease in comparison to the present case.

Case Reports in Dermatological Medicine

Paget Disease of the Vulva: Diagnosis by Immunohistochemistry

Table 1