Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant

Figure 1

Clinical and dermatopathological findings in a patient carrying a novel LEMD3/Man1 (Trp620X) mutation. (a–c) Morphea lesions. (a) Skin lesions involving abdomen. Note indurated periumbilical skin. (b) Close-up highlighting ruptured periumbilical bulla. (c) Indurated skin on chest. (d–g) Histopathology from lesional skin. (d, f) Abdominal skin, H&E, 20x (d) and 50x (f). (e, g) Chest skin, H&E stain 20x (e) and 50x (g).

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