Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant

Figure 2

Histochemistry of lesional skin from patient with LEMD3 Trp620X mutation. (a) H&E stain. (b) Masson’s trichrome staining. (c) Elastin staining. (a1), (b1), and (c1) represent 100x magnification of the epidermis, (a2), (b2), and (c2) represent 100x magnification of the dermis, and (a3), (b3), and (c3) show 630x magnification of the dermis. Note increase in both collagen and elastin deposition and irregular collagen fibrils.