Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant

Table 2

Cases of scleroderma-spectrum disease and LEMD3-type bony lesions.

Study (1st author)	Juvenile-onset linear scleroderma	Adult-onset linear scleroderma	Systemic sclerosis	Generalized morphea	Melorheostosis	Osteopoikilosis
Thompson [49]	x				x
Maroteaux [9]	x				x
Muller [10]	x				x
Pascaud-Ged [50]	x				x
Moreno Alvarez [51]	x				x
Saghafi [7]	x				x
Soffa [52]	x				x
Takeda [53]	x				x
Nakajima [54]	x				x
Miyachi [55]	x				x
Siegel [56]		x			x
Birtane [57]		x			x
Endo [58]		x			x
Shivanand [12]		x			x
Weissmann [6]			x			x
Present case				x		x

x: presence of feature in case report.