Case Report

Mycosis Fungoides of the Oral Cavity: Fungating Tumor Successfully Treated with Electron Beam Radiation and Maintenance Bexarotene

Table 1

Differential diagnosis of oral tumors.

DiseaseOral lesion descriptionDiagnostic clues

Malignancy/premalignancy
 Squamous cell papilloma Discrete exophytic papillary lesions (verruca): occur at any intraoral siteHistory of human immunodeficiency virus infection; association with cutaneous warts on fingers
 Squamous cell carcinoma Nonhealing ulcers, papules, or plaques: occur most frequently at the floor of the mouth and soft palateHistory of tobacco and alcohol consumption; mechanical trauma from ill-fitting dentures

Mesenchymal neoplasms and tumor-like lesions
 Fibrous and vascular overgrowths Discrete lesions of cheek or tongueHistory of chronic irritation, usually from some tooth-related cause or chronic cheek/tongue biting
 Pyogenic granuloma Exuberant overgrowths usually at the gingiva but can occur at any intraoral site May bleed spontaneously or following irritation due to extreme vascularity

Odontogenic tumors and cysts
 Ameloblastoma Oral swellings occurring on the mandible that typically produce multicystic appearance on radiograph Painless and slow growing; untreated, may reach substantial size
 Odontogenic cysts Oral swellings arising adjacent to teeth that usually produce a well-demarcated cyst on radiograph Painless and slow growing