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Case Reports in Dermatological Medicine
Volume 2017 (2017), Article ID 1617375, 3 pages
Case Report

A Case of Disseminated Hypopigmented Keratoses Improved with Oral Acitretin

1Department of Dermatology and Venereology, Akdeniz University School of Medicine Hospital, Antalya, Turkey
2Department of Pathology, Akdeniz University School of Medicine Hospital, Antalya, Turkey
3Hacettepe University School of Medicine, Ankara, Turkey

Correspondence should be addressed to Ali Haydar Eskiocak

Received 5 September 2017; Accepted 4 December 2017; Published 21 December 2017

Academic Editor: Tak-Wah Wong

Copyright © 2017 Ali Haydar Eskiocak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Disseminated hypopigmented keratosis is a distinct clinical entity and only few cases have been reported so far. Here, we present a 21-year-old man with almost 10-year history of hypopigmented, nonfollicular, keratotic lichenoid papules occurring on the extensor surfaces of the extremities, back and lumber region. Histopathological examination showed orthohyperkeratosis, irregular acanthosis, and sporadic papillomatosis with a normal amount of melanin and number of melanocytes. In addition, no marked inflammation or melanophages were seen. In order to exclude other possible causes, we performed laboratory tests and radiological examination which were all found to be normal. As the clinical and histopathological features of our patient were taken into account, it was considered to be compatible with the diagnosis of disseminated hypopigmented keratoses. So far, only topical therapies have been used with failure in the previously reported cases except one patient. Considering the extensive lesions, we treated the present patient with 5% salicylic acid in addition to oral acitretin and significant regression in all lesions was achieved, particularly on the keratosis.