A Case of Granuloma Annulare Associated with Secukinumab Use

Figure 2

Histopathological slides. At 2x magnification (a), there are superficial periadnexal and interstitial granulomatous infiltrates (black arrow). The epidermis is slightly attenuated with subjacent papillary dermal fibrosis (white arrow). At 20x magnification, the superficial dermis (b) contains well-formed granulomas (black arrow) and individual histiocytes that are scaffolded in between collagen bundles; scattered eosinophils are present (white arrow). In the mid dermis (c), there are numerous interstitial histiocytes in small clusters (black arrow) and solitary units (white arrow). Colloidal iron stain (d) reveals interstitial deposition of dermal mucin (black arrow).

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