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Case Reports in Dermatological Medicine
Volume 2018, Article ID 2354146, 4 pages
Case Report

Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma

1St. Joseph’s Hospital Health Center, 301 Prospect Avenue, Syracuse, NY 13203, USA
2Upstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USA

Correspondence should be addressed to Abigail I. Franco; moc.liamg@321dmocnarf.liagiba

Received 25 September 2017; Revised 21 December 2017; Accepted 15 January 2018; Published 21 February 2018

Academic Editor: Alireza Firooz

Copyright © 2018 Abigail I. Franco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the palliative and recurrent setting. This is the first case of concurrent vismodegib and radiation therapy for upfront definitive management. The patient experienced complete response in all treated lesions.