Figure 2: The pituitary carcinoma after 12 cycles of treatment. The pituitary tumor is decreased and limited mostly within the sella (contrast-enhanced MRI). The left temporal lobe is not invaded by the tumor (a). The metastatic brain tumor in the occipital lobe grew smaller, without ringlike enhancement (b). The stalk was then identifiable (a and b). The meningeal dissemination regressed markedly (c). MGMT expression was negative in the pituitary tumor cells. MGMT was positive in the endothelial cells (arrow) and served as the internal positive control. MGMT staining was performed as described in [15].