Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry

<table>Light microscopy image (a) and TOF-SIMS image (b) of the tissue section from the patient pretreated with stable iodine. The green in the TOF-SIMS image represents the signal from iodine and the red marks <svg height="15.9" id="M6" style="vertical-align:-4.18202pt" version="1.1" viewbox="0 0 28.225 15.9" width="28.225" xmlns="http://www.w3.org/2000/svg">
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</svg> (signal from cell membranes). Iodine was located within the follicle lumina. The differences in iodine signal intensity indicate a difference in iodine concentration between the follicle lumina.</table>

Case Reports in Endocrinology

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Figure 3

Figure 3: Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry 

Figure 3 | Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry 