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Case Reports in Endocrinology
Volume 2013 (2013), Article ID 570847, 4 pages
http://dx.doi.org/10.1155/2013/570847
Case Report

TSH-Secreting Pituitary Macroadenoma in a Girl with Lingual Thyroid

1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
2Department of Pathology and Chulalongkorn GenePRO Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
3Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Received 28 June 2013; Accepted 14 August 2013

Academic Editors: G. Aimaretti, J. Broom, W. V. Moore, T. Nagase, and T. Usui

Copyright © 2013 S. Wacharasindhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with long-standing hypothyroid are, in some cases, reported to develop pituitary gland hyperplasia due to loss of feedback inhibition of thyroxine in hypothalamus—the condition of which typically regresses after thyroxine replacement. Herein, a 15-year-old girl—with long-standing untreated lingual hypothyroid—presents with a pathologically proven TSH pituitary macroadenoma and bilateral large ovarian cysts. Although MR imaging may differentiate between hyperplasia and macroadenoma of the pituitary gland, pathological examination is still a cornerstone to correct diagnosis.