Case Report

A 23-Year-Old Female with a Mixed Germ Cell Tumor of the Pituitary Infundibulum: The Challenge of Differentiating Neoplasm from Lymphocytic Infundibuloneurohypophysitis—A Case Report and Literature Review

Table 1

Laboratory studies and CSF studies at initial evaluation.

Laboratory testsPatient’s resultsNormal/reference range

IGF155 ng/mL182–780 ng/mL
GH0.10 ng/mL0.01–8 ng/mL
TSH2.537 mIU/mL0.3–5 mIU/mL
Free T40.66 ng/dL0.8–1.8 ng/dL
Total T31.08 ng/mL0.6–1.81 ng/mL
Estradiol8 pg/mLEarly 10–50; mid 120–375; late cycle 50–155 pg/mL
FSH1.6 mIU/mLFollicular 1.4–9.9; midcycle 6.1–17.2; luteal 1.1–9.2 mIU/mL
LH0.8 mIU/mLFollicular 1.7–15; midcycle 21.9–56.5; luteal 0.6–16.3 mIU/mL
Prolactin24.9 ng/mL0.6–20 ng/mL
ACTH9 pg/mL6–50 pg/mL
Cortisol 8 AM3.7 mcg/dL4–22 mcg/dL
Alpha subunit<0.3 ng/mL<1.5 ng/mL
ACE40 U/L9–67 U/L
CSF Studies
Gross AppearanceClearClear
SupernatantColorlessColorless
RBC1/μL0/μL
WBC1/μL0–5/μL
ACE<4 ACE units<4 ACE units
β 2 Microglobulin0.57 mg/L0.36–2.56 mg/L
Glucose52 mg/dL40–85 mg/dL
Protein26 mg/dL15–45 mg/dL
Alpha Fetoprotein<1.0 ng/mL<1.5 ng/mL
Tumor hCG1 mIU/mLNormal

IGF1: insulin like growth factor 1; GH: growth hormone; TSH: thyroid stimulating hormone; FSH: follicular stimulating hormone; LH: luteinizing hormone; ACTH: adrenocorticotropic hormone; CSF: cerebrospinal fluid; RBC: red blood cells; WBC: white blood cells; ACE: angiotensin converting enzymes.