A 23-Year-Old Female with a Mixed Germ Cell Tumor of the Pituitary Infundibulum: The Challenge of Differentiating Neoplasm from Lymphocytic Infundibuloneurohypophysitis—A Case Report and Literature Review

Table 2

Six adult cases of germinoma mimicking clinically LINH described in the literature.

Age, sex	Clinical presentation	MRI findings	Positive tumor markers	Immunohistochemical findings	Time course	Treatment
21, M [3]	VFD, PHP, DI	Nodular thickening of stalk	Not done	PLAP; CD117	Unclear	Surgery
22, F [4]	VFD, polyuria, weight loss, irregular menstruation	Initial MRI: suprasellar mass with a cystic component; MRI 46 months later: mass enlarged invading optic chiasm	Serum and CSF hCG	No report for specific staining	46 months from initial presentation to final diagnosis	CT
24, F [5]	Headache, PHP	Diffuse thickening of stalk	Serum hCG	PLAP	3-week rapid growth of tumor	RT
24, F [6]	PHP, DI	Diffuse thickening of stalk	Negative serum, CSF hCG, AFP	PLAP; CD117	Unclear	CT, RT
40, F [7]	Headache, diplopia, PH, DI	Intrasellar mass extending to the suprasellar and the clivus	Serum PLAP	CD43; CD45R0; CD20	4 years from initial presentation to final diagnosis	Surgery
45, M [8]	Headache, VFD, secondary hypogonadism	Intrasellar mass extending into right cavernous sinus	CSF hCG	PLAP	1 month of rapid progression	CT, RT

VFD: visual field defect; PHP: panhypopituitarism; DI: diabetes insipidus; CT: chemotherapy; RT: radiotherapy.