Three-Year Successful Cinacalcet Treatment of Secondary Hyperparathyroidism in a Patient with X-Linked Dominant Hypophosphatemic Rickets: A Case Report

Table 1

Effect of cinacalcet treatment on biochemical indices of calcium homeostasis in a patient with X-linked dominant hypophosphatemia.

Plasma (reference interval)	Before cinacalcet treatment	During cinacalcet treatment	𝑃 value
PTH, pmol/L (1.6–6.9)	9.3±3.3	5.4±3.2	0.03
Calcium-ionized, mmol/L (1.18–1.32)	1.25±0.03	1.15±0.04	<0.01
Phosphate, mmol/L (0.76–1.41)	0.84±0.10	0.80±0.08	0.46
Alkaline phosphatase U/L (35–105)	94±7	118±8	<0.001
Calcidiol, nmol/L (50–160)	72±20	72±8	0.96
Creatinine, 𝜇mol/L (45–90)	58±2	61±4	0.17

Mean plasma levels (±standard deviation) in the three years prior to the start of treatment and during three years of treatment with cinacalcet. 𝑃 values denote difference in mean values.