Case Report
Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm
Table 1
Comparison features between oncocytic parathyroid lesions and Hürthle cell thyroid neoplasm.
| | Cytomorphologic features | Oncocytic parathyroid lesions | Hürthle cell thyroid neoplasm |
| | Patterns | Cells isolated and in loose aggregates or syncytial fragments; nuclear overlapping molding; and anisokaryosis | Cells in syncytial fragments; more dyscohesive |
| | Cells | Small 6–9 m in diameter; round to cuboidal | Larger than parathyroid; variable in size |
| | Naked nuclei | Numerous | Few |
| | Nuclei | Small; coarsely granular chromatin | Variably enlarged; fine to coarsely chromatin |
| | Nucleoli | Inconspicuous | Prominent |
| | Cytoplasm | Scant; clear, granular, or eosinophilic | Scant |
| | Colloid | Absent but colloid-like material | Scant/− |
| | IHC studies | | | | PTH |
+ |
− | | TTF-1 |
− |
+ | | Thyroglobulin |
− |
+ | | Chromogranin |
+ |
− |
|
|
PTH: parathyroid hormone; TTF-1: thyroid transcription factor-1; IHC: immunohistochemical.
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