Case Reports in Endocrinology / 2014 / Article / Fig 3

Case Report

Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia Expressing Periostin

Figure 3

Primary formalin fixed tumor tissue and electron microscopic images. (a) Ultrastructural features of spindle shaped stromal cells with organelle-poor cytoplasm and few dense granules (arrow). Orig. mag. × 3125. (b) The granules resemble neurosecretory granules, diameter approx. 200 nm (not typical “dense core” granules), orig. mag. × 10,000. (c) Rounded tumor cell with a nuclear indentation, scant organella, and any cell surface specialized structures. Note singular electron dense granules in cytoplasm (arrows). Orig. mag. × 4,000. (d) Ultrastructural aspect of a giant multinuclear cell displaying in the organelle-rich cytoplasm some vesicular structures with pericentric dense inclusions (arrows). Orig. mag. × 3125.

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