Multifactorial Hypercalcemia and Literature Review on Primary Hyperparathyroidism Associated with Lymphoma
Figure 2
(a) H&E, 40x: sections of the spleen show a proliferation of highly atypical large lymphoid cells resulting in extensive effacement of the splenic architecture. The cells show irregular nuclei with open vesicular chromatin, prominent nucleoli, and moderate to scant cytoplasm. Abundant mitotic figures are seen. (b) Immunohistochemistry, CD20, 40x: the neoplastic lymphoid cells exhibit diffuse and strong staining for CD20. (c) Immunohistochemistry, 1-alpha-hydroxylase, 40x: neoplastic lymphoid cells exhibit moderate, irregular immunoreactivity for 1-alpha-hydroxylase in a cytoplasmic distribution.
