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Case Reports in Endocrinology
Volume 2015, Article ID 161497, 3 pages
http://dx.doi.org/10.1155/2015/161497
Case Report

Primary Adrenal Failure due to Antiphospholipid Syndrome

1Department of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, Turkey
2Clinic of Endocrinology and Metabolism, Necip Fazil State Hospital, 46050 Kahramanmaras, Turkey
3Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, Turkey
4Clinic of Chest Diseases, Necip Fazil State Hospital, 46050 Kahramanmaras, Turkey

Received 2 July 2015; Revised 4 October 2015; Accepted 5 October 2015

Academic Editor: Yuji Moriwaki

Copyright © 2015 Murat Sahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure. Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness. In laboratory examinations, hyponatremia (135 mmol/L), hyperpotassemia (6 mmol/L), and thrombocytopenia (83 K/µL) were determined. Cortisol (1.91 µg/dL) and adrenocorticotropic (550 pg/mL) hormone levels were also evaluated. The patient was hospitalized with a diagnosis of acute adrenal crisis due to primary adrenal insufficiency. A Doppler ultrasound revealed venous thrombosis. The patient was diagnosed with antiphospholipid syndrome after the detection of venous thrombosis, thrombocytopenia, elevated aPTT, and anticardiolipin antibody levels. Anticoagulation treatment was started for antiphospholipid syndrome. The patient is now following up with hydrocortisone, fludrocortisone, and warfarin sodium. Conclusion. Antiphospholipid syndrome is a rare reason for adrenal failure. Antiphospholipid syndrome should be suspected if patients have morbidity secondary to venous-arterial thrombosis.