Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid

Table 1

Comparison of reported MDNC of larynx with hypercalcitoninemia.

	Sweeney et al. (1981) [6]	Smets et al. (1990) [5]	Insabato et al. (1993) [7]	LaBryer et al. (present study)
Age/sex	54-year-old man	55-year-old man	69-year-old man	57-year-old man
Symptomatology	Hoarseness	Hoarseness and dysphagia	Hoarseness	Hoarseness, otalgia, odynophagia
Location of tumor	Left arytenoid,; 3 cervical lymph nodes	Epiglottis,; 3 submandibular lymph nodes	Right arytenoid,; 1 cervical lymph node	Right arytenoid,; 7 cervical lymph nodes
Immunostaining	Calcitonin+; CEA+; TTF-1 – no report	Calcitonin+; CEA+; TTF-1 – no report; Cytokeratin+; Chromogranin A+; NSE+	Calcitonin+; CEA – no report; TTF-1 – no report; Cytokeratin+; Chromogranin A+; NSE+	Calcitonin+; CEA+; TTF-1+ (focally); Cytokeratin+; Chromogranin A+; NSE – not done
Serum calcitonin	1200 ng/L; (ref < 200)	3790 pg/L; (ref < 100)	970 pg/mL; (ref < 300)	157 pg/mL; (ref < 8)
Thyroidectomy specimen	Negative for MTC	Negative for MTC	Diffuse goiter, negative for MTC	4 mm focus of tumor with adjacent intravascular tumor

CEA = carcinoembryonic antigen; TTF-1 = thyroid transcription factor-1; NSE = neuron specific enolase; MTC = medullary thyroid carcinoma.