Case Reports in Endocrinology / 2015 / Article / Tab 1

Case Report

Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid

Table 1

Comparison of reported MDNC of larynx with hypercalcitoninemia.

Sweeney et al. (1981) [6]Smets et al. (1990) [5]Insabato et al. (1993) [7]LaBryer et al. (present study)

Age/sex54-year-old man 55-year-old man69-year-old man 57-year-old man

SymptomatologyHoarsenessHoarseness and dysphagia HoarsenessHoarseness, otalgia, odynophagia

Location of tumorLeft arytenoid,
3 cervical lymph nodes
Epiglottis,
3 submandibular lymph nodes
Right arytenoid,
1 cervical lymph node
Right arytenoid,
7 cervical lymph nodes

ImmunostainingCalcitonin+
CEA+
TTF-1 – no report
Calcitonin+
CEA+
TTF-1 – no report
Cytokeratin+ 
Chromogranin A+
NSE+
Calcitonin+
CEA – no report
TTF-1 – no report
Cytokeratin+
Chromogranin A+
NSE+
Calcitonin+
CEA+
TTF-1+ (focally)
Cytokeratin+
Chromogranin A+
NSE – not done

Serum calcitonin1200 ng/L
(ref < 200)
3790 pg/L
(ref < 100)
970 pg/mL
(ref < 300)
157 pg/mL
(ref < 8)

Thyroidectomy specimenNegative for MTCNegative for MTCDiffuse goiter, negative for MTC4 mm focus of tumor with adjacent intravascular tumor

CEA = carcinoembryonic antigen; TTF-1 = thyroid transcription factor-1; NSE = neuron specific enolase; MTC = medullary thyroid carcinoma.