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Case Reports in Endocrinology
Volume 2015 (2015), Article ID 680191, 5 pages
http://dx.doi.org/10.1155/2015/680191
Case Report

Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism

1St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA
2Division of Neonatology, Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX 79763, USA

Received 20 November 2014; Revised 13 February 2015; Accepted 13 February 2015

Academic Editor: Suat Simsek

Copyright © 2015 Dimitrios Angelis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Maternal Graves’ disease is relatively uncommon with an estimated incidence of 0.4%–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was born at 30-week gestation to a mother with Graves’ disease. Our patient presented with hyperthyroidism followed by transient hypothyroidism requiring treatment with levothyroxine. While hyperthyroid, she was treated with methimazole, iodine, and a beta-blocker. 20 days after the initiation of methimazole, she developed neutropenia. The neutrophil counts started to improve immediately after the initiation of the weaning of methimazole. To the best of our knowledge, this is the first case reported in the literature of methimazole induced neutropenia in a preterm infant being treated for neonatal Graves’ disease.