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Case Reports in Endocrinology
Volume 2015 (2015), Article ID 789762, 4 pages
http://dx.doi.org/10.1155/2015/789762
Case Report

Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy

1Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, AB, Canada T2T 5C7
2Division of Endocrinology and Metabolism, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T3B 6A9
3Division of Pediatric Surgery, Department of Surgery, University of Calgary, Calgary, AB, Canada T3B 6A9

Received 15 September 2015; Accepted 11 November 2015

Academic Editor: Yuji Moriwaki

Copyright © 2015 Alexander A. Leung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined. While preliminary reports suggest that most cases of propylthiouracil-associated birth defects are restricted to the preauricular and urinary systems, careful consideration should be given to other possible manifestations of teratogenicity. We propose that congenital bands may potentially represent a rare yet serious complication of propylthiouracil exposure in early pregnancy, possibly arising from an early mesenteric developmental anomaly. We report a case of a 17-day-old girl that presented with acute small bowel obstruction associated with intestinal malrotation arising from several anomalous congenital bands. Her mother was treated for Graves’ disease during pregnancy with first trimester exposure to propylthiouracil but remained clinically and biochemically euthyroid at conception and throughout the duration of pregnancy. This case suggests that the use of propylthiouracil in early pregnancy may be associated with congenital bands and intestinal malrotation. More reports are needed to further support this association.