Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Thyroid

Figure 2

3: FNA of the thyroid with follicular cells with suspicious nuclei (anisokaryosis, longitudinal grooves) on the background of a lymphocytic thyroiditis (Papanicolaou stain, 400x); 4: macroscopy features of the surgical specimens: left hemithyroidectomy (on top) and left cervical lymph node (on the bottom); 5: thyroid parenchyma with a diffuse infiltration of a lymphoid neoplasm (HE, 40x). These features were also found on the lymph node (not shown); 6: the neoplasm consisted of irregular nodules of follicular dendritic cells (CD21, 40x); 7: extensive background of CD4+ T-lymphocytes (CD4, 40x); 8: intermingled scattered large “popcorn cells” could be observed (HE, 200x); 9: the neoplastic popcorn cells were positive for CD20 (CD20, 200x); 10: they were negative for CD30 (CD30, 200x) and CD15 (not shown).