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Case Reports in Endocrinology
Volume 2017, Article ID 2390797, 5 pages
https://doi.org/10.1155/2017/2390797
Case Report

Coexistence of GH-Producing Pituitary Macroadenoma and Meningioma in a Patient with Multiple Endocrine Neoplasia Type 1 with Hyperglycemia and Ketosis as First Clinical Sign

1Service of Endocrinology and Nutrition, University Clinical Hospital of Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain
2Department of Medicine, University of Salamanca, Campus Miguel de Unamuno, s/n, 37007 Salamanca, Spain
3Cancer Research Institute (IBMCC-CSIC/USAL) and Institute for Biomedical Research, University of Salamanca, Salamanca, Spain
4Service of Anatomic Pathology, University Clinical Hospital of Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain

Correspondence should be addressed to A. Herrero-Ruiz; se.noelyallitsacdulas@rorerreha

Received 29 June 2017; Accepted 10 October 2017; Published 1 November 2017

Academic Editor: Lucy Mastrandrea

Copyright © 2017 A. Herrero-Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present the clinical case of a patient who was admitted with an onset of diabetes mellitus (DM) with associated ketosis and whose clinical, hormonal, and radiological evolution revealed the presence of primary hyperparathyroidism, pancreatic neuroendocrine tumor, and GH-producing pituitary macroadenoma in the context of multiple endocrine neoplasia type 1 (MEN1). DM is relatively common in cases of acromegaly, but it is not generally associated with ketosis. Simultaneously, the patient presented a meningioma, which is associated with pituitary macroadenoma only in extremely rare cases.